"Which skin booster should I get?" is one of the questions I get asked most, and it's a fair one — Profhilo, Seventy Hyal and polynucleotides all get lumped together as "skin boosters," but they don't do the same job. Here's the honest breakdown.
Profhilo: the collagen stimulator
Profhilo is a high-concentration hyaluronic acid injectable — 64mg per 2ml syringe — but it isn't there to plump or hydrate the way a filler does. Instead, that concentration of HA spreads through the tissue and stimulates your own collagen and elastin production.
Best for: skin laxity, crepiness, and an overall loss of firmness — particularly lower face, neck and jawline
Results: build gradually over a course of two treatments, four weeks apart
Longevity: around 6 months before a top-up
If tightening and firming is your main concern, Profhilo is usually my first recommendation.
Seventy Hyal: the hydration booster
Seventy Hyal 2000 is also hyaluronic acid based, but it works differently. It uses active HA fragments across different molecular weights, delivered more superficially to flood the skin's extracellular matrix with hydration.
Best for: dullness, dehydration, and wanting a fast, visible "glow" — great before an event
Results: noticeable hydration and radiance almost immediately
Longevity: typically 6–12 months
Where Profhilo works at a deeper, structural level, Seventy Hyal is more about quality of surface hydration and glow. It's often the better pick if your skin looks tired rather than lax.
Polynucleotides: the repair treatment
Polynucleotides (PN) aren't hyaluronic acid at all — they're derived from purified DNA fragments, and they work as a genuine bio-stimulator. Rather than hydrating, PN encourages your skin's own cells to regenerate, repairing tissue and rebuilding collagen from the inside.
Best for: mature or sun-damaged skin, acne scarring, rough texture, enlarged pores, and under-eye repair
Results: more gradual, but genuinely regenerative rather than just cosmetic
Longevity: effects tend to be longer-lasting because you're changing how the skin behaves, not just adding volume or moisture
This is the one I reach for most often when someone's main concern is skin quality and repair rather than hydration or firmness — I've written before about pairing it with microneedling for exactly that reason.
So which one is right for you?
Honestly, it comes down to what your skin is actually asking for:
Loose, crepey, losing firmness → Profhilo
Dull, dehydrated, wanting a quick glow → Seventy Hyal
Damaged, scarred, textured, wanting deeper repair → Polynucleotides
And for a lot of clients, the real answer isn't picking one — it's combining them across a treatment plan. That's exactly the kind of thing I'd rather talk through properly than guess at over Instagram DMs.
Liz Founder, Novauria Aesthetics
Not sure which skin booster suits you? Book a free consultation — no pressure, just an honest chat.